反应详情

The crude ester (8) (80 mg, 0.35 mmol) was hydrolysed using Method C, except that MeOH (0.8 mL) and 1 M NaOH (0.8 mL) were used. After the reaction, the solvent was removed under a stream of nitrogen gas, acidified using 1N HCl, extracted with EtOAc, dried (MgSO4), filtered and the solvent concentrated in vacuo to give the crude title compound. Yield: 48 mg; HPLC Purity: >66%; LC tr 0.09 min

1. customAfter the reaction
2. customthe solvent was removed under a stream of nitrogen gas
3. extractionextracted with EtOAc
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. concentrationthe solvent concentrated in vacuo