Ethyl pyrrolo[1,2-c]quinazoline-2-carboxylate → 2-Carbethoxy-5,6-dihydropyrrolo[1,2-c]quinazoline

HRID 65922ノート

反応式

HRID 65922 の反応式
[C:1]([C:6]1[CH:7]=[C:8]2[C:17]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[N:11]=[CH:10][N:9]2[CH:18]=1)([O:3][CH2:4][CH3:5])=[O:2]>CO.O=[Pt]=O>[C:1]([C:6]1[CH:7]=[C:8]2[C:17]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[NH:11][CH2:10][N:9]2[CH:18]=1)([O:3][CH2:4][CH3:5])=[O:2]

参加物

4

反応物 1

HCID 4407258Ethyl pyrrolo[1,2-c]quinazoline-2-carboxylate

生成物 1

HCID 227563502-Carbethoxy-5,6-dihydropyrrolo[1,2-c]quinazoline

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 887Methanol溶媒

実験手順

The product of Example II (2.5 g, 0.01 m) was dissolved in MeOH (250 ml). The catalyst, PtO2 (0.5 g), was added and the mixture was hydrogenated at 42 p.s.i. for 3 hrs. Filtration and removal of the solvent in vacuo yielded a white solid. Crystallization from MeOH afforded the product as a white solid; m.p. 140°-141° C.

後処理

  1. filtrationFiltration and removal of the solvent in vacuo
  2. customyielded a white solid
  3. customCrystallization from MeOH

出典と根拠

ORDレコード
ord-d50ec719b5ab40d785f03502f8272481
出典データセット
uspto-grants-1978_12
特許番号
US04129653

反応ノート

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