2-Carbethoxy-5,6-dihydropyrrolo[1,2-c]quinazoline → HCID 22756348、化合物

HRID 65924ノート

反応式

HRID 65924 の反応式
[C:1]([C:6]1[CH:7]=[C:8]2[C:17]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[NH:11][CH2:10][N:9]2[CH:18]=1)([O:3][CH2:4][CH3:5])=[O:2]>C(#N)C=C>[C:1]([C:6]1[CH:7]=[C:8]2[C:17]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[N:11]([CH2:6][CH2:7][C:8]#[N:9])[CH2:10][N:9]2[CH:18]=1)([O:3][CH2:4][CH3:5])=[O:2]

参加物

3

反応物 1

HCID 227563502-Carbethoxy-5,6-dihydropyrrolo[1,2-c]quinazoline

生成物 1

HCID 22756348HCID 22756348、化合物

試薬・触媒・溶媒 1

HCID 7855Acrylonitrile溶媒

実験手順

To a suspension of the product of Example IV (1.5 g, 0.0062 m) in acrylonitrile (5 ml), cooled to 0°-5°, was added, dropwise, 0.4 ml of Triton B over 3 min. An exothermic reaction resulted and a brown colored solution formed. After 5 hr. of reflux, the excess of acrylonitrile was distilled in vacuo, and the semi-solid residue (0.95 g) was crystallized from methanol to afford the desired product; m.p. 102°-104° C.

後処理

  1. temperaturecooled to 0°-5°
  2. additionwas added
  3. customAn exothermic reaction
  4. customresulted
  5. customa brown colored solution formed
  6. waitAfter 5 hr
  7. temperatureof reflux
  8. distillationthe excess of acrylonitrile was distilled in vacuo
  9. customthe semi-solid residue (0.95 g) was crystallized from methanol

出典と根拠

ORDレコード
ord-27e2dd539dd7417fb19c9a7ff90f5cdb
出典データセット
uspto-grants-1978_12
特許番号
US04129653

反応ノート

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