2-Methoxy-4,6-bis(trifluoromethyl)benzoic acid → cis-2-Methoxy-N-(2-pyrrolidin-1-yl-cyclopentyl)-4,6-bis-trifluoromethyl-benzamide

HRID 659266

反応式

HRID 659266 の反応式
[N:1]1([C@H:6]2[CH2:10][CH2:9][CH2:8][C@H:7]2[NH2:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:12][O:13][C:14]1[CH:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[C:19]([C:27]([F:30])([F:29])[F:28])[C:15]=1[C:16](O)=[O:17]>>[CH3:12][O:13][C:14]1[CH:22]=[C:21]([C:23]([F:24])([F:25])[F:26])[CH:20]=[C:19]([C:27]([F:28])([F:29])[F:30])[C:15]=1[C:16]([NH:11][C@@H:7]1[CH2:8][CH2:9][CH2:10][C@@H:6]1[N:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1)=[O:17]

参加物

3

反応物 2

HCID 27412872-Methoxy-4,6-bis(trifluoromethyl)benzoic acidHCID 30820884cis-2-Pyrrolidin-1-yl-cyclopentylamine2 回

生成物 1

HCID 86651462cis-2-Methoxy-N-(2-pyrrolidin-1-yl-cyclopentyl)-4,6-bis-trifluoromethyl-benzamide

実験手順

The title compound, white solid, MS: m/e=425.2 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 2-methoxy-4,6-bis(trifluoromethyl)benzoic acid.

出典と根拠

ORDレコード
ord-00c86bf1f0434c1686e045d62fca7415
出典データセット
uspto-grants-2011_12
特許番号
US08080541B2

関連ノート

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