2,4-Bis(trifluoromethyl)benzamide → 2-Methoxy-6-methylsulfanyl-N-[(1RS,2SR)-2-(4-oxo-piperidin-1-yl)-cyclopentyl]-4-trifluoromethyl-benzamide

HRID 659267

反応式

HRID 659267 の反応式
FC(F)(F)C1C=C(C(F)(F)F)C(C(N)=O)=CC=1.[NH2:18][CH:19]1[CH2:23][CH2:22][CH2:21][CH:20]1[NH:24][C:25](=[O:40])[C:26]1[C:31]([S:32][CH3:33])=[CH:30][C:29]([C:34]([F:37])([F:36])[F:35])=[CH:28][C:27]=1[O:38][CH3:39].[I-].C([N+]1(C)[CH2:49][CH2:48][C:47](=[O:50])[CH2:46][CH2:45]1)C>>[CH3:39][O:38][C:27]1[CH:28]=[C:29]([C:34]([F:36])([F:37])[F:35])[CH:30]=[C:31]([S:32][CH3:33])[C:26]=1[C:25]([NH:24][CH:20]1[CH2:21][CH2:22][CH2:23][CH:19]1[N:18]1[CH2:49][CH2:48][C:47](=[O:50])[CH2:46][CH2:45]1)=[O:40]

参加物

4

反応物 3

HCID 27360992,4-Bis(trifluoromethyl)benzamideHCID 110975681-Ethyl-1-methyl-4-oxopiperidin-1-ium iodideHCID 66681196N-((1RS,2SR)-2-Amino-cyclopentyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide2 回

生成物 1

HCID 666812552-Methoxy-6-methylsulfanyl-N-[(1RS,2SR)-2-(4-oxo-piperidin-1-yl)-cyclopentyl]-4-trifluoromethyl-benzamide

実験手順

The title compound, yellow gum, MS: m/e=431.3 [(M+H)+], was prepared in accordance with the general method of intermediate J from N-((1RS,2SR)-2-amino-cyclopentyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide (intermediate O) and 1-ethyl-1-methyl-4-oxo-piperidinium iodide.

出典と根拠

ORDレコード
ord-8acf14e1272d42778769c8feec2f3a64
出典データセット
uspto-grants-2011_12
特許番号
US08080541B2

関連ノート

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