Water → 6-(3-Hydroxypropyl)-2-methyl-5,6-dihydropyrrolo[1,2-c]quinazoline

HRID 65928ノート

反応式

HRID 65928 の反応式
[H-].[H-].[H-].[H-].[Li+].[Al+3].[CH3:7][C:8]1[CH:9]=[C:10]2[C:19]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[N:13]([CH2:20][CH2:21][C:22](OC)=[O:23])[C:12](=O)[N:11]2[CH:27]=1.O.[OH-].[Na+]>CCOCC>[OH:23][CH2:22][CH2:21][CH2:20][N:13]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:19]=2[C:10]2=[CH:9][C:8]([CH3:7])=[CH:27][N:11]2[CH2:12]1

参加物

6

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 227563572-Methyl-6-(beta-carbomethoxyethyl)pyrrolo[1,2-c]quinazolin-5-one

生成物 1

HCID 227563636-(3-Hydroxypropyl)-2-methyl-5,6-dihydropyrrolo[1,2-c]quinazoline

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

LiAlH4 (2.88 g, 0.076 m) was slurried in ether (250 ml) and to this was added a solution of the product of Example XXXV (5.5 g, 0.019 m) in ether (100 ml). The reaction mixture was stirred at ambient temperature for 1/2 hr. To the reaction mixture was added dropwise and successively H2O (3.0 ml), NaOH (3.0 ml of 15% aqueous), and H2O (9.0 ml). The resulting precipitate was filtered and washed with ether. The solvent was removed in vacuo from the filtrate and the residue crystallized from pentane to yield the desired product as a pale yellow solid; m.p. 77°-78° C.

後処理

  1. additionTo the reaction mixture was added dropwise
  2. filtrationThe resulting precipitate was filtered
  3. washwashed with ether
  4. customThe solvent was removed in vacuo from the filtrate
  5. customthe residue crystallized from pentane

出典と根拠

ORDレコード
ord-b6102c0ae1624cf5b385ea293eb4eb34
出典データセット
uspto-grants-1978_12
特許番号
US04129653

反応ノート

読み込み中…