Triethylamine → Cyclophosphamide
反応式
[Cl:1][CH2:2][CH2:3][N:4]([CH2:9][CH2:10][Cl:11])[P:5](Cl)(Cl)=[O:6].CN[C:14]([C:18]1[CH:23]=CC=CC=1)([OH:17])CC.C([N:26](CC)CC)C>C(OCC)(=O)C>[CH2:18]1[CH2:14][O:17][P:5]([N:4]([CH2:9][CH2:10][Cl:11])[CH2:3][CH2:2][Cl:1])(=[O:6])[NH:26][CH2:23]1参加物
5
実験手順
A solution of bis(2-chloroethyl)phosphoramidic dichloride (10 mmol) in ethyl acetate (100 mL) is added dropwise to a solution of commercial 3 methylamino-1-phenyl-1-propanol (10 mmol) and triethylamine (20 mmol) in ethyl acetate (100 mL) at rt. After stirring at rt for 3 days, the salts are filtered off and the combined filtrates are concentrated under vacuum. The crude product is purified by column chromatography on silica.
後処理
- filtrationthe salts are filtered off
- concentrationthe combined filtrates are concentrated under vacuum
- customThe crude product is purified by column chromatography on silica
出典と根拠
- ORDレコード
- ord-ba24910390c54d239897abdfb963ae7b
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08080536B2
反応ノート
読み込み中…