Triethylamine → Cyclophosphamide

HRID 659310

反応式

HRID 659310 の反応式
[Cl:1][CH2:2][CH2:3][N:4]([CH2:9][CH2:10][Cl:11])[P:5](Cl)(Cl)=[O:6].CN[C:14]([C:18]1[CH:23]=CC=CC=1)([OH:17])CC.C([N:26](CC)CC)C>C(OCC)(=O)C>[CH2:18]1[CH2:14][O:17][P:5]([N:4]([CH2:9][CH2:10][Cl:11])[CH2:3][CH2:2][Cl:1])(=[O:6])[NH:26][CH2:23]1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 96271Phosphoramidic dichloride, bis(2-chloroethyl)-HCID 19933884HCID 19933884、化合物

生成物 1

HCID 2907Cyclophosphamide

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

実験手順

A solution of bis(2-chloroethyl)phosphoramidic dichloride (10 mmol) in ethyl acetate (100 mL) is added dropwise to a solution of commercial 3 methylamino-1-phenyl-1-propanol (10 mmol) and triethylamine (20 mmol) in ethyl acetate (100 mL) at rt. After stirring at rt for 3 days, the salts are filtered off and the combined filtrates are concentrated under vacuum. The crude product is purified by column chromatography on silica.

後処理

  1. filtrationthe salts are filtered off
  2. concentrationthe combined filtrates are concentrated under vacuum
  3. customThe crude product is purified by column chromatography on silica

出典と根拠

ORDレコード
ord-ba24910390c54d239897abdfb963ae7b
出典データセット
uspto-grants-2011_12
特許番号
US08080536B2

関連ノート

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