Hydrogen Bromide → 2-Bromo-5-chloro-6-n-propylsulfamoyl-1-indanone

反応式

[BrH:1].[Cl:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[S:12](=[O:18])(=[O:17])[NH:13][CH2:14][CH2:15][CH3:16])[C:8](=[O:19])[CH2:7][CH2:6]2.BrBr>C(OCC)(=O)C>[Br:1][CH:7]1[CH2:6][C:5]2[C:9](=[CH:10][C:11]([S:12](=[O:17])(=[O:18])[NH:13][CH2:14][CH2:15][CH3:16])=[C:3]([Cl:2])[CH:4]=2)[C:8]1=[O:19]

参加物

実験手順

0.5 L Milliliter of 48% aqueous HBr is added to a solution of 5.76 g (20 mmoles) of 5-chloro-6-n-propylsulfamoyl-1-indanone in 50 ml of ethyl acetate. Thereafter a solution of 3.20 g (20 mmoles) of bromine in 20 ml of ethyl acetate is added dropwise. The mixture is stirred for 1 hour at room temperature, then the solution is concentrated to dryness, and 50 ml of water are added to the residue. The crystalline precipitate is filtered off with suction and washed with water. 2-Bromo-5-chloro-6-n-propylsulfamoyl-1-indanone is obtained which has a melting point of from 150° to 154° C.