Hydrochloric Acid → 6-Amino-5-chloro-2-methyl-1-indanone

HRID 65939ノート

反応式

HRID 65939 の反応式
Cl.[Cl:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[N+:12]([O-])=O)[C:8](=[O:15])[CH:7]([CH3:16])[CH2:6]2>C(O)C.[Fe]>[NH2:12][C:11]1[CH:10]=[C:9]2[C:5]([CH2:6][CH:7]([CH3:16])[C:8]2=[O:15])=[CH:4][C:3]=1[Cl:2]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 227563825-Chloro-2-methyl-6-nitro-1-indanone

生成物 1

HCID 227563766-Amino-5-chloro-2-methyl-1-indanone

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 702Ethanol溶媒

実験手順

13.6 Milliliters of concentrated hydrochloric acid are added dropwise to a mixture of 30.7 g (0.136 mole) of 5-chloro-2-methyl-6-nitro-1-indanone and 24.55 g of iron powder in 340 ml of ethanol, and the suspension is boiled for 4 hours. The mixture is filtered off with suction from the precipitate in a hot state, after which process the compound precipitates partially from the filtrate when cooling. After having distilled off the solvent to a large extent, the precipitate is completed by diluting with water.

後処理

  1. filtrationThe mixture is filtered off with suction from the precipitate in a hot state
  2. customafter which process the compound precipitates partially from the filtrate when
  3. temperaturecooling
  4. distillationAfter having distilled off the solvent to a large extent
  5. additionby diluting with water

出典と根拠

ORDレコード
ord-26e39c63945e46578ad5a38ab426328c
出典データセット
uspto-grants-1978_12
特許番号
US04129656

反応ノート

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