2-Methyl-2-thiopseudourea sulfate → Guanidine Sulfate (1:1)
反応式
CC1[N:3]=[CH:4][NH:5]C=1CSCCN.[S:12]([OH:16])([OH:15])(=[O:14])=[O:13].CSC(=N)[NH2:20]>O>[S:12]([OH:16])([OH:15])(=[O:14])=[O:13].[NH2:3][C:4]([NH2:5])=[NH:20]参加物
4
実験手順
A solution of 4-methyl-5-((2-aminoethyl)thiomethyl)imidazole (19.0 g.) and S-methylisothiourea sulphate (15.1 g.) in water (100 ml.) was heated under reflux for 3 hours. Concentration, acidification with sulphuric acid and dilution with ethanol afforded 2-[(4-methyl-5-imidazolyl)methylthio)ethyl]guanidine sulphate (13.0 g.) m.p. 230°-235° (from aqueous methanol).
後処理
- temperatureunder reflux for 3 hours
- concentrationConcentration, acidification with sulphuric acid and dilution with ethanol
出典と根拠
- ORDレコード
- ord-d142530121634bff9dac22d3af7bde46
- 出典データセット
- uspto-grants-1978_12
- 特許番号
- US04129657
反応ノート
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