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HRID 659530作成日：2026年10月26日

3-(Pyrrolidin-2-yl)pyridine → (3-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}phenyl)-(2-pyridin-3-ylpyrrolidin-1-yl)methanone

https://huagongshe.com/reaction/659530

反応式

関与物質

役割名称HCID仕込み量
反応物3-(Pyrrolidin-2-yl)pyridineHCID 412—
反応物3-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acidHCID 58327807—
生成物(3-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}phenyl)-(2-pyridin-3-ylpyrrolidin-1-yl)methanoneHCID 58327923—

反応手順

3-{1-[5-chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid was reacted with 2-(3-pyridinyl)pyrrolidine as in General Procedure 10 to give the title compound. LCMS: m/z=577.95 (M+H+); retention time=0.65 minutes.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08080561B2
出典データセットuspto-grants-2011_12
ORD IDord-42a6c698b24248e8a70cfce0b7deffd1
出典メモuspto-grants-2011_12