Sodium hydride → 4-[2-(5-Amino-2-methyl-phenylamino)-oxazol-5-yl]-benzonitrile

HRID 659740

反応式

HRID 659740 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:12])=[C:6]([NH:8][C:9](=[O:11])C)[CH:7]=1.[H-].[Na+].ClC1O[C:18]([C:21]2[CH:28]=[CH:27][C:24]([C:25]#[N:26])=[CH:23][CH:22]=2)=[CH:19][N:20]=1>CN(C=O)C>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:12])=[C:6]([NH:8][C:9]2[O:11][C:18]([C:21]3[CH:28]=[CH:27][C:24]([C:25]#[N:26])=[CH:23][CH:22]=3)=[CH:19][N:20]=2)[CH:7]=1

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 794922-Acetylamino-4-aminotolueneHCID 684435584-(2-Chlorooxazol-5-yl)benzonitrile

生成物 1

HCID 177573464-[2-(5-Amino-2-methyl-phenylamino)-oxazol-5-yl]-benzonitrile収率 75%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒3 回

実験手順

A solution of N-(5-Amino-2-methyl-phenyl)-acetamide (1.1 g, 6.7 mmol) in DMF (20 mL) was added to a suspension of NaH (402 mg, 10.05 mmol, 60% dispersion in mineral oil) in DMF (20 mL) at 0° C. under an atmosphere of argon. The mixture was stirred for 30 min. at room temperature and cooled to 0° C. A solution of 4-(2-Chloro-oxazol-5-yl)-benzonitrile (1.37 g, 6.7 mmol) in DMF (20 mL) was added dropwise to the mixture. After 30 min., at 0° C., the reaction was poured into ice water (200 mL). The solid was collected by filtration, washed with water, and dried under vacuum to afford the title compound (1.45 g, 75%). m.p.=228° C.

後処理

  1. temperaturecooled to 0° C
  2. waitAfter 30 min.
  3. filtrationThe solid was collected by filtration
  4. washwashed with water
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-d7c56e3928c54cdc8a2e2742bdd4dd11
出典データセット
uspto-grants-2011_12
特許番号
US08080669B2

関連ノート

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