Anisole → HCID 178521930、化合物

HRID 659807

反応式

HRID 659807 の反応式
[C:1]1([NH:7][C:8]([C:10]2[C:14]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][OH:22])[CH:16]=3)=[CH:13][N:12](CC3C=CC(OC)=CC=3)[N:11]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(OC)C=CC=CC=1>FC(F)(F)C(O)=O>[C:1]1([NH:7][C:8]([C:10]2[C:14]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][OH:22])[CH:16]=3)=[CH:13][NH:12][N:11]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 7519AnisoleHCID 668554221h-Pyrazole-3-carboxamide,4-[3-(hydroxymethyl)phenyl]-1-[(4-methoxyphenyl)methyl]-n-phenyl-

生成物 1

HCID 178521930HCID 178521930、化合物収率 35.2%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

反応条件

温度
120 °C

実験手順

A mixture of 4-(3-hydroxymethyl-phenyl)-1-(4-methoxy-benzyl)-1H-pyrazole-3-carboxylic acid phenylamide (20 mg) and anisole (20 μl) in trifluoroacetic acid (1 ml) was heated at 120° C. (50 W) for 15 minutes in a CEM Discover microwave synthesiser. The reaction was evaporated then purified by flash column chromatography eluting with 2:1 ethyl acetate/hexane. Product containing fractions were combined and evaporated to give 5 mg of product. (LC/MS: Rt 2.55 [M+H]+ 294).

後処理

  1. customThe reaction was evaporated
  2. customthen purified by flash column chromatography
  3. washeluting with 2:1 ethyl acetate/hexane
  4. additionProduct containing fractions
  5. customevaporated

出典と根拠

ORDレコード
ord-3c8789222d134f4ba5277434d4152b95
出典データセット
uspto-grants-2011_12
特許番号
US08080666B2

関連ノート

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