4-Toluenesulfonyl chloride → Oxetan-3-yl 4-methylbenzene-1-sulfonate
反応式
[O:1]1[CH2:4][CH:3]([OH:5])[CH2:2]1.[C:6]1([CH3:16])[CH:11]=[CH:10][C:9]([S:12](Cl)(=[O:14])=[O:13])=[CH:8][CH:7]=1>N1C=CC=CC=1>[O:1]1[CH2:4][CH:3]([O:5][S:12]([C:9]2[CH:10]=[CH:11][C:6]([CH3:16])=[CH:7][CH:8]=2)(=[O:14])=[O:13])[CH2:2]1参加物
4
実験手順
To a solution of oxetan-3-ol (1.0 g, 13.0 mmol) in anhydrous pyridine (25 mL) at room temperature was added 4-toluene sulfonyl chloride (3.09 g, 16.2 mmol). After stirring the reaction mixture for 18 hours at room temperature, the reaction mixture was concentrated under reduced pressure. The resulting residue was purified by flash chromatography over silica gel eluting with a gradient of 0 to 30% ethyl acetate in heptane to afford 1.9 g (62% yield) of the desired product as a white solid.
後処理
- concentrationthe reaction mixture was concentrated under reduced pressure
- customThe resulting residue was purified by flash chromatography over silica gel eluting with a gradient of 0 to 30% ethyl acetate in heptane
出典と根拠
- ORDレコード
- ord-840dc4cf369c4b4ebf7f2b703f48bd51
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08080580B2
反応ノート
読み込み中…