Ammonia → HCID 13359100、化合物

HRID 65994

反応式

HRID 65994 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][N:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.C([O:15][C:16](=O)[CH2:17][C:18](=O)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)C.N>O>[C:7]1([N:5]2[N:6]3[C:16](=[O:15])[CH:17]=[C:18]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[N:1]=[C:2]3[CH:3]=[CH:4]2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 7170Ethyl benzoylacetateHCID 5943201-phenyl-1H-pyrazol-3-amine

生成物 1

HCID 13359100HCID 13359100、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 10 g. of 5-amino-2-phenylpyrazole (0.063 mol.),12.1 g. of benzoylacetic acid ethyl ester (0.063 mol.) and 50 g. of polyphosphoric acid is heated at 110°-120° with stirring for 90 minutes. After cooling, 200 ml. of water and then concentrated aqueous ammonia is added under external cooling to adjust the mixture to pH 9. The collected 1,5-diphenylpyrazolo[1,5-a]pyrimidin-7(1H)-one is washed with water and dried at 70°, yield: 17 g. (94%); m.p. 194°-200°. A sample, recrystallized from absolute ethanol, melts at 205°-207°.

後処理

  1. additionA mixture of 10 g
  2. temperatureAfter cooling
  3. temperatureunder external cooling
  4. washThe collected 1,5-diphenylpyrazolo[1,5-a]pyrimidin-7(1H)-one is washed with water
  5. customdried at 70°
  6. customA sample, recrystallized from absolute ethanol, melts at 205°-207°

出典と根拠

ORDレコード
ord-c89aecfb2a7e473eb71eb9b49edc3698
出典データセット
uspto-grants-1978_12
特許番号
US04129738

関連ノート

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