3-Fluorobenzoic Acid → 3-Fluoro-N-methoxy-N-methylbenzamide
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](O)=[O:6].Cl.[CH3:12][NH:13][O:14][CH3:15].Cl.CN(C)CCCN=C=NCC>ClCCl>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([N:13]([O:14][CH3:15])[CH3:12])=[O:6]参加物
5
実験手順
To a suspension of 3-fluorobenzoic acid (140 mg, 1 mmol) and N,O-dimethylhydroxylamine hydrochloride (107 mg, 1.1 mmol) in dichloromethane (2.5 mL) was added 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (EDC) (211 mg, 1.1 mmol) and the mixture stirred at room temperature for 75 h. The solvents were removed under reduced pressure and the residue chromatographed using ethyl acetate-hexane (4:6) to separate the pure product (130 mg, 71%).
後処理
- customThe solvents were removed under reduced pressure
- customthe residue chromatographed
- customto separate the pure product (130 mg, 71%)
出典と根拠
- ORDレコード
- ord-3edbcc7106be4adca15c4f1c919557f1
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08084456B2
反応ノート
読み込み中…