Sodium Carbonate → 5-Oxo-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acid

HRID 65999ノート

反応式

HRID 65999 の反応式
[O:1]=[C:2]1[C:11]2[CH:10]=[N:9][CH:8]=[N:7][C:6]=2[N:5]([CH2:12][CH3:13])[CH:4]=[C:3]1[C:14]([O:16]CC)=[O:15].C([O-])([O-])=O.[Na+].[Na+]>C(O)(=O)C>[O:1]=[C:2]1[C:11]2[CH:10]=[N:9][CH:8]=[N:7][C:6]=2[N:5]([CH2:12][CH3:13])[CH:4]=[C:3]1[C:14]([OH:16])=[O:15]

参加物

4

反応物 2

HCID 10340Sodium CarbonateHCID 227568395-Oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine

生成物 1

HCID 227568245-Oxo-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acid

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

0.6 g. of this ester and 10 cm3 of a 10% solution of Na2CO3 are heated under reflux for 20 minutes. After cooling, the solution is acidified by means of acetic acid. The precipitate (0.5 g.) is filtered off and recrystallised from water. 0.2 g. of 5-oxo-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acid is obtained, melting point 225° C. (decomposition).

後処理

  1. temperatureunder reflux for 20 minutes
  2. temperatureAfter cooling
  3. filtrationThe precipitate (0.5 g.) is filtered off
  4. customrecrystallised from water

出典と根拠

ORDレコード
ord-ee90deb319b240c99347b3023f21024b
出典データセット
uspto-grants-1978_12
特許番号
US04129737

反応ノート

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