Nitric Acid → HCID 57742139、化合物

HRID 660311ノート

反応式

HRID 660311 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]([CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:5]=[CH:6][CH:7]=1.[N+:15]([O-])([OH:17])=[O:16]>C(O)(=O)C>[OH:1][C:2]1[CH:3]=[C:4]([CH:8]([CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:5]=[CH:6][C:7]=1[N+:15]([O-:17])=[O:16]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 13356241HCID 13356241、化合物

生成物 1

HCID 57742139HCID 57742139、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Ethyl 2-(3-hydroxyphenyl)propanoate (2.51 g, 12.9 mmol) in acetic acid (20 mL) was added nitric acid (60-62%, 1.45 g, 13.8 mmol) at room temperature. The mixture was stirred for 15 minutes at room temperature. The reaction mixture was poured into ice water (100 mL) and extracted with EtOAc. The organic layer was dried with MgSO4 and filtered. EtOAc was removed by evaporation. The residue was purified by column chromatography eluting with n-Hexane/EtOAc=6/1.

後処理

  1. extractionextracted with EtOAc
  2. dry with materialThe organic layer was dried with MgSO4
  3. filtrationfiltered
  4. customEtOAc was removed by evaporation
  5. customThe residue was purified by column chromatography
  6. washeluting with n-Hexane/EtOAc=6/1

出典と根拠

ORDレコード
ord-9c4ab8006cd3451dafe562dfd24a62fe
出典データセット
uspto-grants-2011_12
特許番号
US08084484B2

反応ノート

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