Acetic Acid → HCID 12370788、化合物

HRID 660324ノート

反応式

HRID 660324 の反応式
C([O:3][C:4](=[O:17])[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[C:9]([OH:16])[CH:8]=1)[CH3:6])C.[OH-].[Na+].C(O)(=O)C>CCO.O>[OH:16][C:9]1[CH:8]=[C:7]([CH:5]([CH3:6])[C:4]([OH:17])=[O:3])[CH:12]=[CH:11][C:10]=1[N+:13]([O-:15])=[O:14]

参加物

6

反応物 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 57742139HCID 57742139、化合物

生成物 1

HCID 12370788HCID 12370788、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

反応条件

温度
45 °C

実験手順

To a stirred solution of 2-(3-Hydroxy-4-nitro-phenyl)-propionic acid ethyl ester (1.48 g) in 90% aq. EtOH was added NaOH (1.24 g) at room temperature. After stirred for 14 h at 45° C., the reaction mixture was cooled to room temperature, diluted with water. The resulting aqueous layer was acidified with acetic acid and then extracted with dichloromethane. The combined organic layer was dried over magnesium sulfate, filtered and concentrated in vacuo. (1.30 mg, 99.5%, yellow solid)

後処理

  1. temperaturethe reaction mixture was cooled to room temperature
  2. extractionextracted with dichloromethane
  3. dry with materialThe combined organic layer was dried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-07085aa91fc847f0ba325171bd20f18a
出典データセット
uspto-grants-2011_12
特許番号
US08084484B2

反応ノート

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