Acetic Anhydride → N-(4-(1-Cyanoethyl)phenyl)acetamide

HRID 660352ノート

反応式

HRID 660352 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:11])[C:9]#[N:10])=[CH:4][CH:3]=1.[CH3:12][C:13](OC(C)=O)=[O:14]>N1C=CC=CC=1>[C:9]([CH:8]([CH3:11])[C:5]1[CH:4]=[CH:3][C:2]([NH:1][C:13](=[O:14])[CH3:12])=[CH:7][CH:6]=1)#[N:10]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 1200112-(4-Aminophenyl)propiononitrile

生成物 1

HCID 12226815N-(4-(1-Cyanoethyl)phenyl)acetamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A solution of 2-(4-Amino-phenyl)-propionitrile (10.2 g, 69.8 mmol) in pyridine (40 mL) was added Ac2O (7.49 g, 73.4 mmol) at room temperature. The reaction mixture was refluxed for 1 hrs then cooled to room temperature, and concentrated in vacuo.

後処理

  1. temperatureThe reaction mixture was refluxed for 1 hrs
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-e4ec7258821f44eebb22c09917403a21
出典データセット
uspto-grants-2011_12
特許番号
US08084484B2

反応ノート

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