Isopropylamine → n-Isopropylbenzenesulfonamide
反応式
[CH:1]([NH2:4])([CH3:3])[CH3:2].[C:5]1([S:11](Cl)(=[O:13])=[O:12])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C(Cl)Cl>[CH:1]([NH:4][S:11]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)(=[O:13])=[O:12])([CH3:3])[CH3:2]参加物
4
実験手順
To a solution of isopropylamine (4.2 g, 70.6 mmol) in methylene chloride (50 mL) at 0-5° C. is added dropwise a solution of benzenesulfonyl chloride (5.0 g, 28.3 mmol) in methylene chloride (10 mL). After stirring the mixture at RT for 2 h, the solvent is removed under reduced pressure and 1N HCl is added to the residue. The mixture is extracted with EtOAc and the organic phase is washed with brine then dried over magnesium sulfate. The solvent is removed under reduced pressure to give the title compound as a pale yellow oil.
後処理
- customthe solvent is removed under reduced pressure and 1N HCl
- additionis added to the residue
- extractionThe mixture is extracted with EtOAc
- washthe organic phase is washed with brine
- dry with materialthen dried over magnesium sulfate
- customThe solvent is removed under reduced pressure
出典と根拠
- ORDレコード
- ord-5d62cb63b62440f98ae24ed602102b5a
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08084448B2
反応ノート
読み込み中…