5-[2-Benzyloxy-4-(1-triisopropylsilanyl-1H-pyrrol-3-yl)-phenyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one → HCID 68838285、化合物

反応式

C([O:8][C:9]1[CH:14]=[C:13]([C:15]2[CH:19]=[CH:18][N:17]([Si:20]([CH:27]([CH3:29])[CH3:28])([CH:24]([CH3:26])[CH3:25])[CH:21]([CH3:23])[CH3:22])[CH:16]=2)[CH:12]=[CH:11][C:10]=1[N:30]1[S:34](=[O:36])(=[O:35])[NH:33][C:32](=[O:37])[CH2:31]1)C1C=CC=CC=1>CCO.CCOC(C)=O.CCO.[Pd]>[OH:8][C:9]1[CH:14]=[C:13]([C:15]2[CH:19]=[CH:18][N:17]([Si:20]([CH:21]([CH3:22])[CH3:23])([CH:24]([CH3:25])[CH3:26])[CH:27]([CH3:29])[CH3:28])[CH:16]=2)[CH:12]=[CH:11][C:10]=1[N:30]1[S:34](=[O:36])(=[O:35])[NH:33][C:32](=[O:37])[CH2:31]1

参加物

実験手順

To a slurry of Pd/C (10 mg) in 10 mL of EtOH/EtOAc (1:1) is added a solution of 5-[2-benzyloxy-4-(1-triisopropylsilanyl-1H-pyrrol-3-yl)-phenyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one in EtOH. The mixture is stirred under an atmosphere of H2 for 18 h then the catalyst is removed by filtration through a pad of Celite. The filtrate is concentrated under reduced pressure to afford the title compound which is used directly in the next step: (M−1)−=448.