Potassium tert-butoxide → HCID 68838475、化合物
反応式
[NH2:1][S:2]([N:5]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19](=[O:27])[O:20][CH2:21][CH2:22][Si:23]([CH3:26])([CH3:25])[CH3:24])=[CH:13][C:12]=1[O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH2:6][C:7](OC)=[O:8])(=[O:4])=[O:3].CC(C)([O-])C.[K+]>C1COCC1>[CH3:24][Si:23]([CH3:26])([CH3:25])[CH2:22][CH2:21][O:20][C:19](=[O:27])[CH2:18][O:17][C:14]1[CH:15]=[CH:16][C:11]([N:5]2[CH2:6][C:7](=[O:8])[NH:1][S:2]2(=[O:4])=[O:3])=[C:12]([O:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:13]=1参加物
4
実験手順
To a solution of methyl N-(aminosulfonyl)-N-(2-(benzyloxy)-4-{2-oxo-2-[2-(trimethylsilyl)ethoxy]ethoxy}phenyl)glycinate in THF is added potassium t-butoxide (1.1 equivalent) in THF dropwise. The mixture is stirred at RT for 18 h. The solvent is removed under reduced pressure to afford the title compound which is used directly in the next step.