4-Chlorobenzohydrazide → HCID 47133870、化合物

HRID 660838

反応式

HRID 660838 の反応式
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH2:9])=[O:7])=[CH:4][CH:3]=1.[CH:12]1([N:15]=[C:16]=[O:17])[CH2:14][CH2:13]1>O1CCCC1>[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH:9][C:16]([NH:15][CH:12]2[CH2:14][CH2:13]2)=[O:17])=[O:7])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 108164-ChlorobenzohydrazideHCID 637659Isocyanatocyclopropane

生成物 1

HCID 47133870HCID 47133870、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
50 °C

実験手順

Under an argon atmosphere, 4.00 g (23.4 mmol) of 4-chlorobenzoic acid hydrazide are placed in 50 ml tetrahydrofuran. 1.95 g (23.4 mmol) of cyclopropyl isocyanate, dissolved in 50 ml tetrahydrofuran, are added dropwise at 50° C., and the mixture further stirred overnight at 50° C. The solvent is evaporated in vacuo, diethyl ether is added to the residue and the solid formed is isolated and purified by filtration and further washing with diethyl ether. 5.92 g (ca. 100% of theory) of the target compound are thus obtained.

後処理

  1. additionare added dropwise at 50° C.
  2. customThe solvent is evaporated in vacuo, diethyl ether
  3. additionis added to the residue
  4. customthe solid formed
  5. customis isolated
  6. filtrationpurified by filtration
  7. washfurther washing with diethyl ether
  8. custom5.92 g (ca. 100% of theory) of the target compound are thus obtained

出典と根拠

ORDレコード
ord-814020fe38114f1f9d9dedf11305c678
出典データセット
uspto-grants-2011_12
特許番号
US08084481B2

関連ノート

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