3-Chlorobenzohydrazide → HCID 47131865、化合物

HRID 660839

反応式

HRID 660839 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([NH:7][NH2:8])=[O:6].[CH:12]1([N:15]=[C:16]=[O:17])[CH2:14][CH2:13]1>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([NH:7][NH:8][C:16]([NH:15][CH:12]1[CH2:14][CH2:13]1)=[O:17])=[O:6]

参加物

4

反応物 2

HCID 742893-ChlorobenzohydrazideHCID 637659Isocyanatocyclopropane

生成物 1

HCID 47131865HCID 47131865、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Under an argon atmosphere, 430 mg (2.52 mmol) of 3-chlorobenzoic acid hydrazide are placed in 6 ml tetrahydrofuran. 209 mg (2.52 mmol) of cyclopropyl isocyanate, dissolved in 2 ml tetrahydrofuran is added dropwise and further stirred overnight at room temperature. It is concentrated and purified by stirring the residue with diethyl ether, filtration, further washing with diethyl ether and drying in vacuo. 514 mg (80% of theory) of the target compound are thus obtained.

後処理

  1. additionis added dropwise and further stirred overnight at room temperature
  2. concentrationIt is concentrated
  3. custompurified
  4. filtrationwith diethyl ether, filtration
  5. washfurther washing with diethyl ether
  6. customdrying in vacuo
  7. custom514 mg (80% of theory) of the target compound are thus obtained

出典と根拠

ORDレコード
ord-c617a670b8b54eb2adcb26308e061f78
出典データセット
uspto-grants-2011_12
特許番号
US08084481B2

関連ノート

読み込み中…