p-Toluohydrazide → 1-Methyl-3-[(4-methylbenzoyl)amino]urea
反応式
[CH3:1][NH:2][C:3](=O)[O:4]C1C=CC([N+]([O-])=O)=CC=1.C(N(CC)C(C)C)(C)C.[CH3:24][C:25]1[CH:34]=[CH:33][C:28]([C:29]([NH:31][NH2:32])=[O:30])=[CH:27][CH:26]=1>ClCCl>[CH3:1][NH:2][C:3]([NH:32][NH:31][C:29](=[O:30])[C:28]1[CH:27]=[CH:26][C:25]([CH3:24])=[CH:34][CH:33]=1)=[O:4]参加物
5
実験手順
653 mg (3.33 mmol) of 4-nitrophenyl methylcarbamate and 473 mg (3.22 mmol) of N,N-diisopropylethylamine are added to 500 mg (3.33 mmol) of 4-methylbenzoic acid hydrazide in 15 ml dichloromethane and the mixture stirred overnight at room temperature. The precipitate formed is recovered by filtration, washed with diethyl ether and dried in vacuo. 602 mg (87% of theory) of the target compound are thus obtained.
後処理
- customThe precipitate formed
- filtrationis recovered by filtration
- washwashed with diethyl ether
- customdried in vacuo
- custom602 mg (87% of theory) of the target compound are thus obtained
出典と根拠
- ORDレコード
- ord-6b5361132a2e41c3816495284ebab3d1
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08084481B2
反応ノート
読み込み中…