ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Potassium Carbonate → 2-[3-(4-chlorophenyl)-4-(4-methoxyphenylmethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-N-[3-(trifluoromethyl)phenylmethyl]acetamide

HRID 660929
ノート
印刷プレビュー

反応式

HRID 660929 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[C:10](=[O:13])[NH:11][N:12]=2)=[CH:4][CH:3]=1.Cl[CH2:24][C:25]([NH:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:38])([F:37])[F:36])[CH:30]=1)=[O:26].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[C:10](=[O:13])[N:11]([CH2:24][C:25]([NH:27][CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:36])([F:37])[F:38])[CH:30]=3)=[O:26])[N:12]=2)=[CH:4][CH:3]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 212778322-Chloro-N-(3-trifluoromethyl-benzyl)-acetamideHCID 580122805-(4-chlorophenyl)-4-(4-methoxybenzyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

生成物 1

HCID 580120502-[3-(4-chlorophenyl)-4-(4-methoxyphenylmethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-N-[3-(trifluoromethyl)phenylmethyl]acetamide

試薬・触媒・溶媒 1

HCID 6342
Acetonitrile
溶媒

実験手順

1.00 g (3.17 mmol) of 5-(4-chlorophenyl)-4-(4-methoxyphenylmethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one from Example 55A, 0.80 g (3.17 mmol) of 2-chloro-N-[3-(trifluoromethyl)phenylmethyl]-acetamide and 0.88 g (6.33 mmol) of potassium carbonate are suspended in 20 ml of acetonitrile and heated under reflux for 8 hrs. The mixture is then concentrated in vacuo, and the residue taken up in water and extracted three times with ethyl acetate. The combined organic phases are concentrated and the residue purified by preparative HPLC [Method 12]. 1.07 g (64% of theory) of the target compound are thus obtained.

後処理

  1. temperatureheated
  2. temperatureunder reflux for 8 hrs
  3. concentrationThe mixture is then concentrated in vacuo
  4. extractionextracted three times with ethyl acetate
  5. concentrationThe combined organic phases are concentrated
  6. customthe residue purified by preparative HPLC [Method 12]
  7. custom1.07 g (64% of theory) of the target compound are thus obtained

出典と根拠

ORDレコード
ord-1ae5b52e72924f09ac2e98b71b17b431
出典データセット
uspto-grants-2011_12
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08084481B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート