Potassium Carbonate → N-phenethyl-N-propyl-3-methoxyphenethylamine

HRID 66127

反応式

HRID 66127 の反応式
[CH2:1](I)[CH2:2][CH3:3].C(=O)([O-])[O-].[K+].[K+].[CH2:11]([NH:19][CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=1)[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CC(C)=O>[CH2:11]([N:19]([CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=1)[CH2:1][CH2:2][CH3:3])[CH2:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 336431-IodopropaneHCID 12477997N-phenethyl-3-methoxyphenethylamine

生成物 1

HCID 12478003N-phenethyl-N-propyl-3-methoxyphenethylamine

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

1.1 ml of propyl iodide and 1.1 g of potassium carbonate were added to a solution of 1.1 g of the product of Step A in 15 ml of acetone and the mixture was refluxed with stirring for 5 hours. The acetone was distilled under reduced pressure and 50 ml of water were added thereto. The mixture was extracted 3 times with 20 ml of methylene chloride and the combined organic phases were washed with 70 ml of aqueous sodium chloride solution. The organic phases were dried over magnesium sulfate, filtered and evaporated to dryness under reduced pressure to obtain 1.25 g of N-phenethyl-N-propyl-3-methoxyphenethylamine in the form of an orange oil.

後処理

  1. temperaturethe mixture was refluxed
  2. distillationThe acetone was distilled under reduced pressure and 50 ml of water
  3. additionwere added
  4. extractionThe mixture was extracted 3 times with 20 ml of methylene chloride
  5. washthe combined organic phases were washed with 70 ml of aqueous sodium chloride solution
  6. dry with materialThe organic phases were dried over magnesium sulfate
  7. filtrationfiltered
  8. customevaporated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-513f67831ac641ba96946d2e51567ccf
出典データセット
uspto-grants-1978_12
特許番号
US04130658

関連ノート

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