Potassium Carbonate → 3-methoxy-N-[2-(3-methoxyphenyl)-ethyl]-N-propyl-benzene-ethanamine

HRID 66128ノート

反応式

HRID 66128 の反応式
Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:10][C:11]([NH:13][CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[CH:17]=2)=O)[CH:7]=[CH:8][CH:9]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:30](I)[CH2:31][CH3:32]>CC(C)=O>[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][N:13]([CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[CH:17]=2)[CH2:30][CH2:31][CH3:32])[CH:7]=[CH:8][CH:9]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 336431-IodopropaneHCID 227557503-methoxy-N-[2-(3-methoxyphenyl)-ethyl]-benzene-ethanamide hydrochloride

生成物 1

HCID 124780053-methoxy-N-[2-(3-methoxyphenyl)-ethyl]-N-propyl-benzene-ethanamine収率 97.3%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A suspension of 8.75 g of the product of Step A, 17.5 g of calcined neutral potassium carbonate, 17.5 g of propyl iodide and 180 ml of acetone was refluxed for 61/2 hours under nitrogen and the mixture was then filtered. The filtrate was evaporated to dryness and the residue was taken up in ether. The ether solution was washed with water, dried and evaporated to dryness to obtain 8.3 g of 3-methoxy-N-[2-(3-methoxyphenyl)-ethyl]-N-propyl-benzene-ethanamine which was used as is for the next step.

後処理

  1. temperaturewas refluxed for 61/2 hours under nitrogen
  2. filtrationthe mixture was then filtered
  3. customThe filtrate was evaporated to dryness
  4. washThe ether solution was washed with water
  5. customdried
  6. customevaporated to dryness

出典と根拠

ORDレコード
ord-5ee94f4a4866432ba586e76f53bf5f20
出典データセット
uspto-grants-1978_12
特許番号
US04130658

反応ノート

読み込み中…