4,7-dihydro-4,7-dioxo-1-(2-propynyl)-6-(2-propynyloxy)-1H-cyclohepta[b]pyridine-2-carboxylic Acid ethyl ester → HCID 53707130、化合物

HRID 66147ノート

反応式

HRID 66147 の反応式
[CH2:1]([O:3][C:4]([C:6]1[N:11]([CH2:12][C:13]#[CH:14])[C:10]2[CH:15]=[CH:16][C:17](=[O:24])[C:18]([O:20][CH2:21][C:22]#[CH:23])=[CH:19][C:9]=2[C:8](=[O:25])[CH:7]=1)=[O:5])[CH3:2].[H][H]>[Pd].C(O)(=O)C>[CH2:1]([O:3][C:4]([C:6]1[N:11]([CH2:12][CH2:13][CH3:14])[C:10]2[CH:15]=[CH:16][C:17](=[O:24])[C:18]([O:20][CH2:21][CH2:22][CH3:23])=[CH:19][C:9]=2[C:8](=[O:25])[CH:7]=1)=[O:5])[CH3:2]

参加物

5

反応物 2

HCID 544541564,7-dihydro-4,7-dioxo-1-(2-propynyl)-6-(2-propynyloxy)-1H-cyclohepta[b]pyridine-2-carboxylic Acid ethyl esterHCID 178418361HCID 178418361、化合物

生成物 1

HCID 53707130HCID 53707130、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 176Acetic Acid溶媒

実験手順

A mixture of 4,7-dihydro-4,7-dioxo-1-(2-propynyl)-6-(2-propynyloxy)-1H-cyclohepta[b]pyridine-2-carboxylic acid ethyl ester (20 g, described in Example 20), 5% palladium on charcoal (2.0 g) and acetic acid (400 ml) is stirred rapidly under an atmosphere of hydrogen until 5.7 liters of hydrogen are absorbed. The mixture is filtered and the filtrate is evaporated. The residue is subjected to chromatography on silica gel using acetone-hexane (1:1). The eluates are evaporated to give a residue of the title compound.

後処理

  1. customare absorbed
  2. filtrationThe mixture is filtered
  3. customthe filtrate is evaporated
  4. customThe eluates are evaporated

出典と根拠

ORDレコード
ord-a9d8d5c7c1394be18af0176ae4a3c433
出典データセット
uspto-grants-1978_12
特許番号
US04130649

反応ノート

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