8-Phenoxy-1,4-dioxaspiro[4.5]decane → 4-Phenoxycyclohexanone
反応式
[O:1]([CH:8]1[CH2:17][CH2:16][C:11]2(OCC[O:12]2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1COCC1.Cl>[O:1]([CH:8]1[CH2:9][CH2:10][C:11](=[O:12])[CH2:16][CH2:17]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
Step 2 A solution of 8-phenoxy-1,4-dioxaspiro[4.5]decane (0.460 g, 1.963 mmol) in THF (5.0 mL) and 3 M hydrochloric acid (5 mL) was stirred at rt for 2 days. The mixture was extracted with EtOAc, and the organic phase was washed with brine, dried and concentrated to provide 4-phenoxycyclohexanone as a colorless oil (0.344 g, 92%). 1H NMR (500 MHz, chloroform-d) δ 7.22-7.27 (2H, m), 6.87-6.94 (3H, m), 4.62-4.66 (1H, m), 2.59-2.68 (2H, m), 2.19-2.30 (4H, m), 1.96-2.04 (2H, m). Mass spectrum m/z 191.1 (M+H)+.
後処理
- extractionThe mixture was extracted with EtOAc
- washthe organic phase was washed with brine
- customdried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-691db10ccff44e4faac7f56075e1df8d
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08084620B2
反応ノート
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