Bromine → 5-Bromo-2-methoxybenzonitrile

HRID 662036

反応式

HRID 662036 の反応式
[Br:1]Br.[CH3:3][O:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[C:7]#[N:8]>C(Cl)(Cl)Cl>[Br:1][C:10]1[CH:11]=[CH:12][C:5]([O:4][CH3:3])=[C:6]([CH:9]=1)[C:7]#[N:8]

参加物

4

反応物 2

HCID 24408BromineHCID 810862-Methoxybenzonitrile

生成物 1

HCID 44185605-Bromo-2-methoxybenzonitrile収率 71.4%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

Br2 (13.7 g, 86.0 mmol) in CHCl3 (20 mL) was added to a solution of 2-(methyloxy)benzonitrile (10.9 g, 81.9 mmol) in CHCl3 (50 mL). The mixture was refluxed for 29 h. The reaction was allowed to cool to room temperature, and washed with saturated sodium bisulfite (50 mL), and brine (50 mL). The organic layer was dried over anhydrous sodium sulfate. Evaporation of the solvent afforded 5-bromo-2-(methyloxy)benzonitrile (12.4 g, 71%).

後処理

  1. temperatureThe mixture was refluxed for 29 h
  2. washwashed with saturated sodium bisulfite (50 mL), and brine (50 mL)
  3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  4. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-ee9078e3cb3d4d9ca94b6bdff0d821a7
出典データセット
uspto-grants-2011_12
特許番号
US08084449B2

関連ノート

読み込み中…