Ethanol → 2-(4-Chlorophenoxy)-N-(2-cyanoethyl)-2-methylpropanamide
反応式
C(O)C.[Na].[Cl:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.[C:13]([CH2:15][CH2:16][NH:17][C:18](=[O:23])[C:19](Br)([CH3:21])[CH3:20])#[N:14]>C1(C)C=CC=CC=1>[C:13]([CH2:15][CH2:16][NH:17][C:18](=[O:23])[C:19]([O:12][C:9]1[CH:10]=[CH:11][C:6]([Cl:5])=[CH:7][CH:8]=1)([CH3:21])[CH3:20])#[N:14]参加物
6
実験手順
Into a 25 liter reactor fitted with cooling and stirring means there were poured 3 liters of ethanol, 60 g of sodium and 250 g of p-chlorophenol (1.944 mol). After stirring for 1 hour there were added 3 liters of toluene and the ethanol/toluene azeotrope was removed by distillation; 2 more liters of toluene were added and also 425 g of N-cyanoethyl α -bromo-isobutyramide, (1.944 mol).
後処理
- customInto a 25 liter reactor fitted
- temperaturewith cooling
- stirringAfter stirring for 1 hour there
- customthe ethanol/toluene azeotrope was removed by distillation
- addition2 more liters of toluene were added
出典と根拠
- ORDレコード
- ord-39df1e5f7f404323818a74e6bd196d9e
- 出典データセット
- uspto-grants-1978_12
- 特許番号
- US04131617
反応ノート
読み込み中…