Pyridine → 6-chloro-4'-[5-chloro-2-(1-methanesulfonyl-4-piperidinyloxy)-phenyl]-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

反応式

[CH3:40][S:41]([Cl:42])(=[O:43])=[O:44].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:9]([cH:10]1)[NH:8][C:7](=[O:11])[C:6]21[CH:12]([c:32]2[c:33]([CH3:39])[cH:34][cH:35][c:36]([F:38])[cH:37]2)[NH:13][C:14](=[O:31])[CH2:15][CH:16]1[c:17]1[c:18]([O:24][CH:25]2[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]2)[cH:19][cH:20][c:21]([Cl:23])[cH:22]1.[Cl:51][CH2:52][Cl:53].[cH:45]1[cH:46][cH:47][n:48][cH:49][cH:50]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:9]([cH:10]1)[NH:8][C:7](=[O:11])[C:6]21[CH:12]([c:32]2[c:33]([CH3:39])[cH:34][cH:35][c:36]([F:38])[cH:37]2)[NH:13][C:14](=[O:31])[CH2:15][CH:16]1[c:17]1[c:18]([O:24][CH:25]2[CH2:26][CH2:27][N:28]([S:41]([CH3:40])(=[O:43])=[O:44])[CH2:29][CH2:30]2)[cH:19][cH:20][c:21]([Cl:23])[cH:22]1