4-Chlorobenzoyl chloride → (4-Chlorophenyl)[1-(4-chlorophenyl)-3-azabicyclo[3.1.0]hexan-3-yl]methanone

HRID 66277

反応式

HRID 66277 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]23[CH2:13][CH:12]2[CH2:11][NH:10][CH2:9]3)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Na+].[Na+].[Cl:20][C:21]1[CH:29]=[CH:28][C:24]([C:25](Cl)=[O:26])=[CH:23][CH:22]=1>C1C=CC=CC=1>[Cl:20][C:21]1[CH:29]=[CH:28][C:24]([C:25]([N:10]2[CH2:11][CH:12]3[C:8]([C:5]4[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=4)([CH2:13]3)[CH2:9]2)=[O:26])=[CH:23][CH:22]=1

参加物

5

反応物 3

HCID 85014-Chlorobenzoyl chlorideHCID 10340Sodium CarbonateHCID 101303311-(4-Chlorophenyl)-3-azabicyclo[3.1.0]hexane

生成物 1

HCID 20468348(4-Chlorophenyl)[1-(4-chlorophenyl)-3-azabicyclo[3.1.0]hexan-3-yl]methanone

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A 19.35 g sample of 1-p-chlorophenyl-3-azabicyclo[3.1.0]hexane, 10.59 g of sodium carbonate and 17.5 g of p-chlorobenzoyl chloride are reacted in benzene. The benzene is evaporated and the dark purple residue is dissolved in 200 ml of chloroform and washed successively with 5% sodium carbonate, 0.5N hydrochloric acid and then with water and dried over sodium sulfate giving a dark purple oil. Addition of ether gives the product 3-p-chlorobenzoyl-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane as grey crystals, mp 98°-100° C.

後処理

  1. customThe benzene is evaporated
  2. dissolutionthe dark purple residue is dissolved in 200 ml of chloroform
  3. washwashed successively with 5% sodium carbonate, 0.5N hydrochloric acid
  4. dry with materialwith water and dried over sodium sulfate giving a dark purple oil
  5. additionAddition of ether

出典と根拠

ORDレコード
ord-a2b0bc96875c46f5a91b3eee54438da1
出典データセット
uspto-grants-1978_12
特許番号
US04131611

関連ノート

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