Benzoyl Peroxide → Ethyl 2-bromo-2-(3,4-dichlorophenyl)acetate

HRID 66285

反応式

HRID 66285 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].[Br:15]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:15][CH:9]([C:4]1[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1)[C:10]([O:12][CH2:13][CH3:14])=[O:11]

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 2737422Ethyl 3,4-dichlorophenylacetate

生成物 1

HCID 12717583Ethyl 2-bromo-2-(3,4-dichlorophenyl)acetate

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

In a three-necked flask fitted with a Nichrome stirrer and a reflux condenser is placed 7.0 g of ethyl 3,4-dichlorophenylacetate, 5.9 g of N-bromosuccinimide, 0.1 g of benzoyl peroxide and 150 ml of carbon tetrachloride. The reaction mixture is heated at reflux for 18 hours, cooled and filtered. The carbon tetrachloride filtrate is concentrated under reduced pressure to give a deep orange liquid. Vacuum distillation at 115°-120° C. (0.5 mm) gives ethyl α-bromo-3,4-dichlorophenylacetate as a pale yellow liquid.

後処理

  1. customIn a three-necked flask fitted with a Nichrome stirrer and a reflux condenser
  2. temperatureThe reaction mixture is heated
  3. temperatureat reflux for 18 hours
  4. temperaturecooled
  5. filtrationfiltered
  6. concentrationThe carbon tetrachloride filtrate is concentrated under reduced pressure
  7. customto give a deep orange liquid
  8. distillationVacuum distillation at 115°-120° C. (0.5 mm)

出典と根拠

ORDレコード
ord-8bb4d254d7f440ec8351d60f1eca7e2b
出典データセット
uspto-grants-1978_12
特許番号
US04131611

関連ノート

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