Propylenediamine → 1-Methyl-2-(3-phenylureido)ethylamine

HRID 66329

反応式

HRID 66329 の反応式
[C:1]1([NH:7][C:8](=[O:12])OCC)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:13][CH2:14][CH:15]([NH2:17])[CH3:16]>>[CH3:16][CH:15]([NH2:17])[CH2:14][NH:13][C:8]([NH:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)=[O:12]

参加物

3

反応物 2

HCID 6567PropylenediamineHCID 7591Ethyl N-phenylcarbamate

生成物 1

HCID 536666351-Methyl-2-(3-phenylureido)ethylamine

反応条件

温度
125 °C

実験手順

A mixture of ethyl phenylcarbamate (50 g.) and 1,2-diaminopropane (105 g.) is heated at 125° C. for 17 hours and cooled, and the excess of amine is removed by evaporation under reduced pressure. The residue is dissolved in ethyl acetate and the solution is washed with saturated brine, dried and evaporated to dryness. The residue is triturated with toluene and there is thus obtained as solid residue 1-methyl-2-(3-phenylureido)ethylamine, which is used without further purification.

後処理

  1. temperaturecooled
  2. customthe excess of amine is removed by evaporation under reduced pressure
  3. dissolutionThe residue is dissolved in ethyl acetate
  4. washthe solution is washed with saturated brine
  5. customdried
  6. customevaporated to dryness
  7. customThe residue is triturated with toluene and there

出典と根拠

ORDレコード
ord-129ebabf9e89424b8767af64051836c2
出典データセット
uspto-grants-1978_12
特許番号
US04131685

関連ノート

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