Nitric Acid → 6-Methyl-2-nitropyridin-3-ol
反応式
[OH:1][C:2]1[CH:3]=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.[N+:9]([O-])([OH:11])=[O:10]>>[OH:1][C:2]1[C:3]([N+:9]([O-:11])=[O:10])=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1参加物
3
反応条件
- 温度
- 6 °C
実験手順
To 40 ml. of ice cold concentrated sulfuric acid was added 10.9 g. of 3-hydroxy-6-methylpyridine. Maintaining the temperature at 6° C., 4.7 ml. of fuming nitric acid was added dropwise with stirring. The mixture was allowed to warm to room temperature overnight. Ice (200 g.) was added with stirring. After the ice had melted, the precipitate was collected, washed with water and dried to give 3-hydroxy-6-methyl-2-nitropyridine, m.p. 103°-105° C.
後処理
- additionof ice cold concentrated sulfuric acid was added 10.9 g
- temperatureto warm to room temperature overnight
- stirringwith stirring
- customthe precipitate was collected
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-f3b692fa11714b5f803b8edbedaeef34
- 出典データセット
- uspto-grants-1978_12
- 特許番号
- US04131677
反応ノート
読み込み中…