Nitric Acid → 6-Methyl-2-nitropyridin-3-ol

HRID 66353

反応式

HRID 66353 の反応式
[OH:1][C:2]1[CH:3]=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.[N+:9]([O-])([OH:11])=[O:10]>>[OH:1][C:2]1[C:3]([N+:9]([O-:11])=[O:10])=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 944Nitric AcidHCID 142752-Methyl-5-hydroxypyridine

生成物 1

HCID 848016-Methyl-2-nitropyridin-3-ol

反応条件

温度
6 °C

実験手順

To 40 ml. of ice cold concentrated sulfuric acid was added 10.9 g. of 3-hydroxy-6-methylpyridine. Maintaining the temperature at 6° C., 4.7 ml. of fuming nitric acid was added dropwise with stirring. The mixture was allowed to warm to room temperature overnight. Ice (200 g.) was added with stirring. After the ice had melted, the precipitate was collected, washed with water and dried to give 3-hydroxy-6-methyl-2-nitropyridine, m.p. 103°-105° C.

後処理

  1. additionof ice cold concentrated sulfuric acid was added 10.9 g
  2. temperatureto warm to room temperature overnight
  3. stirringwith stirring
  4. customthe precipitate was collected
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-f3b692fa11714b5f803b8edbedaeef34
出典データセット
uspto-grants-1978_12
特許番号
US04131677

関連ノート

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