Pyridine → N-(3-(Oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide

HRID 66356

反応式

HRID 66356 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[O:9][C:10]3[C:11]([N:16]=2)=[N:12][CH:13]=[CH:14][CH:15]=3)[CH:5]=[CH:6][CH:7]=1.N1C=CC=CC=1.[C:23](OC(=O)C)(=[O:25])[CH3:24]>O>[C:23]([NH:1][C:2]1[CH:3]=[C:4]([C:8]2[O:9][C:10]3[C:11]([N:16]=2)=[N:12][CH:13]=[CH:14][CH:15]=3)[CH:5]=[CH:6][CH:7]=1)(=[O:25])[CH3:24]

参加物

5

反応物 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 6110863-(Oxazolo[4,5-b]pyridin-2-yl)aniline

生成物 1

HCID 2995970N-(3-(Oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 0.63 g. of 2-(3-aminophenyl)oxazolo[4,5-b]pyridine in 10 ml. of pyridine was treated with 0.35 ml. of acetic anhydride with stirring. After stirring over the weekend the mixture was diluted to 50 ml. with water. After stirring a short time and cooling, the precipitate was collected, washed with water and dried. Recrystallization from ethyl acetate gave 2-(3-acetamidophenyl)oxazolo[4,5-b]pyridine, m.p. 201.5-202.5.

後処理

  1. additionwas diluted to 50 ml
  2. stirringAfter stirring a short time
  3. temperaturecooling
  4. customthe precipitate was collected
  5. washwashed with water
  6. customdried
  7. customRecrystallization from ethyl acetate

出典と根拠

ORDレコード
ord-c8282c7f83c448a3bc9223f140a8bc7b
出典データセット
uspto-grants-1978_12
特許番号
US04131677

関連ノート

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