2-Fluorobenzoyl chloride → 3-(2-Fluorobenzoylamino)-2-pyridone
反応式
[NH2:1][C:2]1[C:3](=[O:8])[NH:4][CH:5]=[CH:6][CH:7]=1.[F:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12](Cl)=[O:13]>N1C=CC=CC=1>[F:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12]([NH:1][C:2]1[C:3](=[O:8])[NH:4][CH:5]=[CH:6][CH:7]=1)=[O:13]参加物
4
実験手順
To a solution of 3.3 g. (0.03 mole) of 3-amino-2-pyridone in 75 ml. of pyridine cooled in ice was added portionwise 6.3 g. (0.04 mole) of 2-fluorobenzoyl chloride over 5 minutes. After stirring for 15 hours at ambient temperature, the mixture was poured into ice-water. The resultant precipitate was collected by filtration, washed with water and recrystallized from ethanol to give 3-(2-fluorobenzoylamino)-2-pyridone, m.p. 223° C.
後処理
- additionwas added portionwise 6.3 g
- filtrationThe resultant precipitate was collected by filtration
- washwashed with water
- customrecrystallized from ethanol
出典と根拠
- ORDレコード
- ord-6cd5c49560994244a0d836c696125f9b
- 出典データセット
- uspto-grants-1978_12
- 特許番号
- US04131677
反応ノート
読み込み中…