Nitric Acid → 3-Nitro-5-(trifluoromethyl)pyridin-2-ol

HRID 66364

反応式

HRID 66364 の反応式
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]([F:15])([F:14])[C:7]1[CH:8]=[CH:9][C:10](=[O:13])[NH:11][CH:12]=1>>[N+:1]([C:9]1[C:10](=[O:13])[NH:11][CH:12]=[C:7]([C:6]([F:15])([F:5])[F:14])[CH:8]=1)([O-:4])=[O:2]

参加物

3

反応物 2

HCID 944Nitric AcidHCID 1474432-Hydroxy-5-(trifluoromethyl)pyridine

生成物 1

HCID 27750933-Nitro-5-(trifluoromethyl)pyridin-2-ol

実験手順

To 0.95 l. of stirred fuming nitric acid was added 29 g. of 5-trifluoromethyl-2-pyridone over 1 hour, and stirring was continued for 75 hours. The fuming nitric acid was evaporated and the residue was triturated with acetone. The acetone was evaporated to about 60 ml. and the precipitate was collected on a filter and washed with a 5:1 mixture of methylene chloride:acetone and dried and used directly in the next step.

後処理

  1. customThe fuming nitric acid was evaporated
  2. customthe residue was triturated with acetone
  3. customThe acetone was evaporated to about 60 ml
  4. customand the precipitate was collected on
  5. filtrationa filter
  6. washwashed with a 5:1 mixture of methylene chloride
  7. dry with materialacetone and dried

出典と根拠

ORDレコード
ord-4ef501ed967540b5aac24abf05f09fce
出典データセット
uspto-grants-1978_12
特許番号
US04131677

関連ノート

読み込み中…