3-oxazolo[4,5-b]pyridin-2-ylBenzonitrile → 2-[3-(Aminomethyl)phenyl]oxazolo[4,5-b]pyridine
反応式
[C:1]([C:3]1[CH:4]=[C:5]([C:9]2[O:10][C:11]3[C:12]([N:17]=2)=[N:13][CH:14]=[CH:15][CH:16]=3)[CH:6]=[CH:7][CH:8]=1)#[N:2]>O=[Pt]=O.C(O)(=O)C>[NH2:2][CH2:1][C:3]1[CH:4]=[C:5]([C:9]2[O:10][C:11]3[C:12]([N:17]=2)=[N:13][CH:14]=[CH:15][CH:16]=3)[CH:6]=[CH:7][CH:8]=1参加物
4
実験手順
A mixture of 2-(3-cyanophenyl)oxazolo[4,5-b]pyridine (2.2 g., 0.01 m.), 200 ml. of glacial acetic acid and 1.0 g. of PtO2 catalyst is reacted in a 40 p.s.i. hydrogen atmosphere at room temperature until the theoretical amount of hydrogen has been absorbed. The mixture is filtered, the acetic acid removed in vacuo to yield 2-[3-(aminomethyl)phenyl]oxazolo[4,5-b]pyridine.
後処理
- customhydrogen atmosphere at room temperature until the theoretical amount of hydrogen has been absorbed
- filtrationThe mixture is filtered
- customthe acetic acid removed in vacuo
出典と根拠
- ORDレコード
- ord-0332988be29a4c06b83ddc640fd7ea17
- 出典データセット
- uspto-grants-1978_12
- 特許番号
- US04131677
反応ノート
読み込み中…