Imidazole → Trimethyl[(oct-1-yn-4-yl)oxy]silane

HRID 66401

反応式

HRID 66401 の反応式
[OH:1][CH:2]([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:3][C:4]#[CH:5].N1C=CN=C1.Cl[Si:16]([CH3:19])([CH3:18])[CH3:17]>CN(C)C=O>[CH3:17][Si:16]([CH3:19])([CH3:18])[O:1][CH:2]([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:3][C:4]#[CH:5]

参加物

5

反応物 3

HCID 795ImidazoleHCID 6397ChlorotrimethylsilaneHCID 1036561-Octyn-4-ol

生成物 1

HCID 12786181Trimethyl[(oct-1-yn-4-yl)oxy]silane

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a cold solution of 166 g of 4-hydroxy-1-octyne [Prostaglandins, 10, 289 (1975)] , and 240 g of imidazole in one liter of dimethylformamide is added dropwise 202 g of chlorotrimethylsilane. The mixture is allowed to stand at room temperature for 2 to 3 days. The mixture is partitioned with water and hexane. The hexane layer is washed with brine, dried over magnesium sulfate, and concentrated. Distillation of the residue gives a colorless liquid, b.p. 38° (0.2mm).

後処理

  1. customThe mixture is partitioned with water and hexane
  2. washThe hexane layer is washed with brine
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated
  5. distillationDistillation of the residue
  6. customgives a colorless liquid, b.p. 38° (0.2mm)

出典と根拠

ORDレコード
ord-3568b4a541224a9686c22814bb253b2e
出典データセット
uspto-grants-1978_12
特許番号
US04131737

関連ノート

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