Methyl iodide → 2-Imino-3,5-dimethyl-4-(1,3,4)-thiadiazoline hydroiodide

HRID 66563

反応式

HRID 66563 の反応式
[CH3:1][I:2].[NH2:3][C:4]1[S:5][C:6]([CH3:9])=[N:7][N:8]=1>C(O)(C)C>[IH:2].[NH:3]=[C:4]1[N:8]([CH3:1])[N:7]=[C:6]([CH3:9])[S:5]1

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 669491,3,4-Thiadiazole, 2-amino-5-methyl-

生成物 1

HCID 705411252-Imino-3,5-dimethyl-4-(1,3,4)-thiadiazoline hydroiodide

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

64.1 g of methyl iodide are added to a solution of 17.6 g of 2-amino-5-methyl-1,3,4-thiadiazole in 350 ml isopropanol. The solution is refluxed for 15 hours. The reaction mixture is then evaporated to dryness, the crystalline evaporation residue is stirred with ethyl acetate and the solvent is filtered off with suction. The crystalline residue is washed, first with ethyl acetate and then with ether, and then dried. 2-Imino-3,5-dimethyl-4-(1,3,4) -thiadiazoline hydroiodide with a melting point of 208° (decomposition) is thus obtained.

後処理

  1. temperatureThe solution is refluxed for 15 hours
  2. customThe reaction mixture is then evaporated to dryness
  3. filtrationthe solvent is filtered off with suction
  4. washThe crystalline residue is washed, first with ethyl acetate
  5. dry with materialwith ether, and then dried

出典と根拠

ORDレコード
ord-bf3f6cd9eeb340b9976ab9527da93279
出典データセット
uspto-grants-1982_08
特許番号
US04342764

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