Hydrochloric Acid → 6-Bromo-5-chloro-2[(methylthio) (methoxy)acetyl]-3-(2-pyridyl)indole

HRID 66566ノート

反応式

HRID 66566 の反応式
Cl.[Br:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)=[C:8]([C:12](=[O:17])[CH2:13][S:14]([CH3:16])=O)[NH:9]2)=[CH:5][C:4]=1[Cl:24].[OH2:25].[CH3:26]O>O1CCCC1>[Br:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)=[C:8]([C:12](=[O:17])[CH:13]([S:14][CH3:16])[O:25][CH3:26])[NH:9]2)=[CH:5][C:4]=1[Cl:24]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 962WaterHCID 173465Sch 24937

生成物 1

HCID 205304266-Bromo-5-chloro-2[(methylthio) (methoxy)acetyl]-3-(2-pyridyl)indole

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Add 2 ml of concentrated hydrochloric acid to 6-bromo-5-chloro-2[(methylsulfinyl)acetyl]-3-(2-pyridyl)indole (5.0 g) in 50 ml of methanol and 50 ml of tetrahydrofuran, warm the mixture to 60° for 2 hours. Cool, add water and the resulting solid is collected and dried to obtain 6-bromo-5-chloro-2[(methylthio) (methoxy)acetyl]-3-(2-pyridyl)indole.

後処理

  1. temperaturewarm the mixture to 60° for 2 hours
  2. temperatureCool
  3. customthe resulting solid is collected
  4. customdried

出典と根拠

ORDレコード
ord-76705779064d47da967d22936e4fe364
出典データセット
uspto-grants-1982_08
特許番号
US04342769

反応ノート

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