Ethyl chloroformate → HCID 20278947、化合物

HRID 66676ノート

反応式

HRID 66676 の反応式
[C:1](Cl)(=[O:5])[O:2][CH2:3][CH3:4].[CH3:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]([CH:16]1[CH2:21][CH2:20][N:19](CC2C=CC=CC=2)[CH2:18][CH2:17]1)=[O:15]>CC1C=CC=CC=1C>[CH3:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]([CH:16]1[CH2:21][CH2:20][N:19]([C:1]([O:2][CH2:3][CH3:4])=[O:5])[CH2:18][CH2:17]1)=[O:15]

参加物

4

反応物 2

HCID 10928Ethyl chloroformateHCID 20530712(1-Benzylpiperidin-4-yl)(2-methylphenyl)methanone

生成物 1

HCID 20278947HCID 20278947、化合物

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

A mixture of 12 parts of ethyl carbonochloridate, 31 parts of (2-methylphenyl)[1-(phenylmethyl)-4-piperidinyl]methanone and 270 parts of dimethylbenzene is stirred and refluxed for 4 hours. The reaction mixture is evaporated and the residue is dissolved in trichloromethane. The solution is washed with a dilute hydrochloric acid solution. The organic phase is separated, dried, filtered and evaporated, yielding 20 parts of ethyl 4-(2-methylbenzoyl)-1-piperidinecarboxylate as an oily residue.

後処理

  1. temperaturerefluxed for 4 hours
  2. customThe reaction mixture is evaporated
  3. dissolutionthe residue is dissolved in trichloromethane
  4. washThe solution is washed with a dilute hydrochloric acid solution
  5. customThe organic phase is separated
  6. customdried
  7. filtrationfiltered
  8. customevaporated

出典と根拠

ORDレコード
ord-1a443255c825462d802ee0bfad41c6bf
出典データセット
uspto-grants-1982_08
特許番号
US04342870

反応ノート

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