Methane → 4-(Cyanomethoxy)benzonitrile

HRID 66765

反応式

HRID 66765 の反応式
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1)#[N:2].C([O-])([O-])=O.[K+].[K+].Cl[CH2:17][C:18]#[N:19].C>CC(Cl)(Cl)Cl.O.CN(C)C=O>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([O:9][CH2:17][C:18]#[N:19])=[CH:5][CH:4]=1)#[N:2]

参加物

8

反応物 4

HCID 297MethaneHCID 7856ChloroacetonitrileHCID 11430Potassium CarbonateHCID 130194-Cyanophenol

生成物 1

HCID 205290614-(Cyanomethoxy)benzonitrile

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒HCID 62781,1,1-Trichloroethane溶媒

反応条件

温度
5 °C

実験手順

The compound of 4-cyanophenoxyacetonitrile was prepared by heating 29.8 g of 4-cyanophenol, 44.8 g of anhydrous K2CO3, 40 ml of dimethylformamide and 18.75 g of chloroacetonitrile with stirring in a round-bottomed three-necked flask at 70°-80° C. for 3 hours, after which time the reaction mixture was poured into an ice and water mixture, which resulted in crystal formation. The crystals were separated by filtering and were then washed with water. After drying a pale tan solid was obtained which was then dissolved in methylchloroform at reflux temperature, treated with activated charcoal and filtered. The filtrate was cooled to 5° C. and the resulting crystals filtered and dried to give the 4-cyanophenoxyacetonitrile.

後処理

  1. customThe compound of 4-cyanophenoxyacetonitrile was prepared
  2. customresulted in crystal formation
  3. customThe crystals were separated
  4. filtrationby filtering
  5. washwere then washed with water
  6. customAfter drying a pale tan solid
  7. customwas obtained which
  8. temperatureat reflux temperature
  9. filtrationfiltered
  10. filtrationthe resulting crystals filtered
  11. customdried

出典と根拠

ORDレコード
ord-00053850eedf48998b805479552470f3
出典データセット
uspto-grants-1982_08
特許番号
US04343808

関連ノート

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