Hydrochloric Acid → 8-Methoxy-4-[(2-methylphenyl)amino]-3-quinolinecarboxylic Acid

HRID 66776ノート

反応式

HRID 66776 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[CH:10][C:9]([C:13]([O:15]CC)=[O:14])=[C:8]2[NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[CH3:25].[OH-].[Na+].C(O)C.Cl>O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[CH:10][C:9]([C:13]([OH:15])=[O:14])=[C:8]2[NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[CH3:25]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 130384398-Methoxy-4-o-tolylamino-quinoline-3-carboxylic acid ethyl ester

生成物 1

HCID 130384408-Methoxy-4-[(2-methylphenyl)amino]-3-quinolinecarboxylic Acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of Ethyl 8-methoxy-4-[(2-methylphenyl)amino]-3-quinolinecarboxylate, 15.00 g (0.0445 mole), 100 ml of 3 N sodium hydroxide solution and 100 ml of ethanol was stirred at room temperature for 16 hours. The mixture was diluted with 300 ml of water and acidified to pH 6.8 with 6 N hydrochloric acid solution. The precipitate was collected by filtration, washed in succession with water and acetone and air dried for about 1.5 hr. Weight of solid was 13.41 g (98%), m.p. 272° C. (d).

後処理

  1. filtrationThe precipitate was collected by filtration
  2. washwashed in succession with water and acetone and air
  3. customdried for about 1.5 hr

出典と根拠

ORDレコード
ord-01be616c14cc409ba37998d98552c46b
出典データセット
uspto-grants-1982_08
特許番号
US04343804

反応ノート

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