Quinone → 7,8,9,10-Tetrahydro-11-(4-pyridyl)-6H-azepino[1,2-a]indole-3-ol

HRID 66823

反応式

HRID 66823 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]=[C:8]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][NH:9]2)=[CH:3][CH:2]=1.[C:15]1(=O)[CH:20]=[CH:19][C:18](=[O:21])[CH:17]=[CH:16]1>C(Cl)(Cl)Cl>[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[C:15]3[C:16](=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=3)[N:9]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:8]=23)=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 4650QuinoneHCID 705496552-(4-Picolinylidene)1,3,4,5,6,7-hexahydroazepine

生成物 1

HCID 205291797,8,9,10-Tetrahydro-11-(4-pyridyl)-6H-azepino[1,2-a]indole-3-ol

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

One hundred and forty-one grams (0.75 mole) of 2-(4-picolinylidene)1,3,4,5,6,7-hexahydroazepine were dissolved in 1000 ml of chloroform and mixed under ice cooling with a solution of 89 g (0.83 mole) of 1,4-benzoquinone in 1000 ml of chloroform added dropwise. After the mixture stood for 24 hours at room temperature, the precipitate formed was filtered, suspended in 500 ml of dimethylformamide, and then heated for two hours to 100° C. After cooling, the suspension was suction filtered and washed with dimethylformamide and acetone, whereby the pure 2-hydroxy-isomer was obtained.

後処理

  1. additionadded dropwise
  2. customthe precipitate formed
  3. filtrationwas filtered
  4. temperatureheated for two hours to 100° C
  5. temperatureAfter cooling
  6. filtrationfiltered
  7. washwashed with dimethylformamide and acetone, whereby the pure 2-hydroxy-isomer
  8. customwas obtained

出典と根拠

ORDレコード
ord-a85841b2f3f94a06bf8c65be4734c04c
出典データセット
uspto-grants-1982_08
特許番号
US04343811

関連ノート

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