Toluene → 5-(2-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole

HRID 66935

反応式

HRID 66935 の反応式
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1.[C:11]1([CH3:20])[C:12]([C:17](Cl)=[O:18])=[CH:13][CH:14]=[CH:15][CH:16]=1.C1(C)C=CC=CC=1>C1(C)C(C)=CC=CC=1>[C:11]1([CH3:20])[C:12]([C:17]([NH:1][C:2]2[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=2)=[O:18])=[CH:13][CH:14]=[CH:15][CH:16]=1

参加物

5

反応物 3

HCID 1140TolueneHCID 702762-Methylbenzoyl chlorideHCID 6028483-(Trichloromethyl)-1,2,4-thiadiazol-5-amine

生成物 1

HCID 130415145-(2-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole収率 35.1%

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

A solution of 22.0 g (0.1 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 16.0 g (0.1 mole) 2-toluoyl chloride in 250 ml xylene was heated at reflux for 20 hours. The reaction mixture was cooled to room temperature and the resulting precipitate removed by filtration. Following recrystallization for toluene, 11.8 g (35% yield) of pure product was otained; m.p. 170° C.

後処理

  1. temperatureat reflux for 20 hours
  2. customthe resulting precipitate removed by filtration

出典と根拠

ORDレコード
ord-40e39dbc987749c18435765ac008b42e
出典データセット
uspto-grants-1982_08
特許番号
US04343945

関連ノート

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